Men and women do not have the same relation between body composition and bone mineral density in Brazilian people
ALONSO, A. C.; RIBEIRO, T. C.; FERREIRA, R. B.; DUARTE, R.; BRECH, G. C.; SILVA, L. X.; BOCALINI, D. S.; PETERSON, M.; MAIFRINO, L. B. M.; GREVE, J. M. D. A.
Abstract
Objectives: The main objective this study was to examine if lean mass and the adiposity related with BMD in a eutrophic population of Brazilian adults, in different sites and gender. Methods: A crossectional observational study, without intervention. One hundred non-obese men and women, aged 20-40 years, who did not practice regular physical activity were evaluated. Body composition analysis was conducted by dual energy X-ray absorptiometry (DXA), and multiple regression was used to examine the sex-specific association between adiposity and lean mass profiles. Results: Even after adjusting for age, sex, and BMI, total fat mass was inversely associated with total BMD (?=-4.52 g/cm2 , p<0.01). Lean mass was positively associated with BMD and female groups. In our study the lean mass has a postive effect in BMD for eutrophic Brazilian adults, opposite of adiposity. Although when stratified by gender, in adults women lean mass and adiposity have positive effects on BMD, which did not happen with men.
Keywords
References
BIAN, P., LI, X., YING, Q., CHEN, J., JIN, X., YAO, J. and SHOU, Z. Factors associated with low femoral neck bone mineral density in very elderly Chinese males. Archives of Gerontology and Geriatrics, 2015, vol. 61, n. 3, p. 484-488. PMid:26279395. http://dx.doi.org/10.1016/j.archger.2015.08.010.
BOGL, LH., LATVALA, A., KAPRIO, J., SOVIJÄRVI, O., RISSANEN, A. and PIETILÄINEN, KH. An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample. Journal of Bone and Mineral Research, 2011, vol. 26, n. 1, p. 79-87. PMid:20658559. http://dx.doi.org/10.1002/jbmr.192.
BREDELLA, MA., GILL, CM., GERWECK, AV., LANDA, MG., KUMAR, V., DALEY, SM., TORRIANI, M. and MILLER, KK. Ectopic and serum lipid levels are positively associated with bone marrow fat in obesity. Radiology, 2013, vol. 269, n. 2, p. 534-541. PMid:23861502. http://dx.doi.org/10.1148/radiol.13130375.
GOODPASTER, BH., KELLEY, DE., THAETE, FL., HE, J. and ROSS, R. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. Journal of Applied Physiology, 2000, vol. 89, p. 104-110.
GOWER, BA. and CASAZZA, K. Divergent effects of obesity on bone health. Journal of Clinical Densitometry, 2013, vol. 16, n. 4, p. 450-454. PMid:24063845. http://dx.doi.org/10.1016/j.jocd.2013.08.010.
HO-PHAM, LT., NGUYEN, ND., LAI, TQ. and NGUYEN, TV. Contributions of lean mass and fat mass to bone mineral density: a study in postmenopausal women. BMC Musculoskeletal Disorders, 2010, vol. 26, n. 11, p. 59.
HSU, YH., VENNERS, SA., TERWEDOW, HA., FENG, Y., NIU, T., LI, Z., LAIRD, N., BRAIN, JD., CUMMINGS, SR., BOUXSEIN, ML., ROSEN, CJ. and XU, X. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. The American Journal of Clinical Nutrition, 2006, vol. 83, n. 1, p. 146-154. PMid:16400063.
JIANG, Y., ZHANG, Y., JIN, M., GU, Z., PEI, Y. and MENG, P. Aged related changes in body composition and association between body composition with bone mass density by body mass index in chinese han men over 50-year-old. PLoS One, 2015, vol. 10, n. 6, p. e0130400.
JOHNELL, O. and KANIS, JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporosis International, 2006, vol. 17, n. 12, p. 1726-1733. PMid:16983459. http://dx.doi.org/10.1007/s00198-006-0172-4.
KIN, K., KUSHIDA, K., YAMAZAKI, K., OKAMOTO, S. and INOUE, T. Bone mineral density of the spine in normal Japanese subjects using dual-energy X-ray absorptiometry: effect of obesity and menopausal status. Calcified Tissue International, 1991, vol. 49, n. 2, p. 101-106. PMid:1913287. http://dx.doi.org/10.1007/BF02565129.
PARK, JH., SONG, YM., SUNG, J., LEE, K., KIM, YS., KIM, T. and CHO, SI. The association between fat and lean mass and bone mineral density: the Healthy Twin Study. Bone, 2012, vol. 50, n. 4, p. 1006-1011. PMid:22306928. http://dx.doi.org/10.1016/j.bone.2012.01.015.
PASCO, JA., GOULD, H., BRENNAN, SL., NICHOLSON, GC. and KOTOWICZ, MA. Musculoskeletal deterioration in men accompanies increases in body fat. Obesity, 2014, vol. 22, n. 3, p. 863-867. PMid:23625641. http://dx.doi.org/10.1002/oby.20496.
PLUIJM, SM., VISSER, M., SMIT, JH., POPP-SNIJDERS, C., ROOS, JC. and LIPS, P. Determinants of bone mineral density in older men and women: body composition as mediator. Journal of Bone and Mineral Research, 2001, vol. 16, n. 11, p. 2142-2151. PMid:11697812. http://dx.doi.org/10.1359/jbmr.2001.16.11.2142.
REID, IR. Relationships between fat and bone. Osteoporosis International, 2008, vol. 19, n. 5, p. 595-606. PMid:17965817. http://dx.doi.org/10.1007/s00198-007-0492-z.
SCHAFER, AL., VITTINGHOFF, E., LANG, TF., SELLMEYER, DE., HARRIS, TB., KANAYA, AM., STROTMEYER, ES., CAWTHON, PM., CUMMINGS, SR., TYLAVSKY, FA., SCHERZINGER, AL. and SCHWARTZ, AV. Body Composition S. Fat infiltration of muscle, diabetes, and clinical fracture risk in older adults. The Journal of Clinical Endocrinology and Metabolism, 2010, vol. 95, n. 11, p. E368-E372. PMid:20668037. http://dx.doi.org/10.1210/jc.2010-0780.
SHAO, HD., LI, GW., LIU, Y., QIU, YY., YAO, JH. and TANG, GY. Contributions of fat mass and fat distribution to hip bone strength in healthy postmenopausal Chinese women. Journal of Bone and Mineral Metabolism, 2015, vol. 33, n. 5, p. 507-515. PMid:25269857. http://dx.doi.org/10.1007/s00774-014-0613-7.
SILVA, HG., MENDONÇA, LM., CONCEIÇÃO, FL., ZAHAR, SE. and FARIAS, ML. Influence of obesity on bone density in postmenopausal women. Arquivos Brasileiros de Endocrinologia e Metabologia, 2007, vol. 51, n. 6, p. 943-949. PMid:17934661. http://dx.doi.org/10.1590/S0004-27302007000600008.
VAN LANGENDONCK, L., CLAESSENS, AL., LEFEVRE, J., THOMIS, M., PHILIPPAERTS, R., DELVAUX, K., LYSENS, R., VANDEN EYNDE, B. and BEUNEN, G. Association between bone mineral density (DXA), body structure and body composition in middle aged men. American Journal of Human Biology, 2002, vol. 14, n. 6, p. 735-742. PMid:12400034. http://dx.doi.org/10.1002/ajhb.10090.
VETTOR, R., MILAN, G., FRANZIN, C., SANNA, M., DE COPPI, P., RIZZUTO, R. and FEDERSPIL, G. The origin of intermuscular adipose tissue and its pathophysiological implications. American Journal of Physiology. Endocrinology and Metabolism, 2009, vol. 297, n. 5, p. E987-E998. PMid:19738037. http://dx.doi.org/10.1152/ajpendo.00229.2009.
WONG, AK., BEATTIE, KA., MIN, KK., GORDON, C., PICKARD, L., PAPAIOANNOU, A. and ADACHI, JD. Peripheral quantitative computed tomography-derived muscle density and peripheral magnetic ressonance imaging-derived muscle adiposity: precision and associations with fragility fractures in women. Journal of Musculoskeletal & Neuronal Interactions, 2014, vol. 14, n. 4, p. 401-410. PMid:25524965.
ZHANG, P., PETERSON, M., SU, GL. and WANG, SC. Visceral adiposity is negatively associated with bone density and muscle attenuation. The American Journal of Clinical Nutrition, 2015, vol. 101, n. 2, p. 337-343. PMid:25646331. http://dx.doi.org/10.3945/ajcn.113.081778.
ZHU, K., HUNTER, M., JAMES, A., LIM, EM. and WALSH, JP. Associations between body mass index, lean and fat body mass and bone mineral density in middle-aged Australians: The Busselton Healthy Ageing Study. Bone, 2015, vol. 74, p. 146-152. PMid:25652209. http://dx.doi.org/10.1016/j.bone.2015.01.015.