Sarcopenia is a multi-factorial process that can be characterized by morphological changes. Mounting of evidence suggests that loss of motor neurons and structural changes on the neuromuscular junction (NMJ) may contribute to the progression of skeletal muscle aging. Other studies revealed that the age-related changes in NMJ morphology vary among different skeletal muscle types and could potentially be related to muscle activity levels. Thus, the aim of the present study was to do a critical and systematic review about the impact of aging on the NMJ morphology of limb muscles. We used Pubmed database and the following keywords: "neuromuscular junction" AND aging AND morphology. A systematic review was done and eight papers were retrieved. Several mechanisms are implicated at the etiology of sarcopenia. Oxidative stress, growth factors and stabilization proteins are involved in the maintenance of the integrity of the neuromuscular junction morphology and any disturbance might trigger denervation predominance.