Journal of Morphological Sciences
http://www.jms.periodikos.com.br/article/587cb4be7f8c9d0d058b4846
Journal of Morphological Sciences
Original Article

Comparative study of the kidneys from dystrophic mice

Oliveira, D.M.; Santos, A.C.; Bertassoli, B.M.; Viana, D.C.; Prado, AAF.; A.C. Assis Neto

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Abstract

The Duchenne Muscular Dystrophy (DMD) is a recessive genetic disease linked to chromosome X. This disease is characterized by an absence or dysfunction in the expression of dystrophin. Experimental models mdx are widely used for the development of research addressing the DMD. The objective of this research is to contribute to a detailed study of possible renal morphological changes resulting from DMD. We used five pairs of kidneys from mdx mice and five from normal mice, which were subjected to measurement, light microscopy, and scanning electron microscopy. The morphological findings of kidneys from mdx mice are within the patterns described in animal studies with severe dehydration, which exhibit signs of diffuse hemorrhage in the cortical and medullary area, while the glomeruli in the cortical region showed a decrease in urinary space, located between the Bowman’s capsule and the inner cell mass of the glomeruli. However, future experiments with animals in different ages can assist in the proving of the morphological changes found here.

Keywords

dehydration, Duchenne Muscular Dystrophy, glomeruli, kidneys
587cb4be7f8c9d0d058b4846 jms Articles
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J. Morphol. Sci.

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