The aim of this study was to review the literature to see how the protocols are designed to induce knee joint muscles fatigue using an isokinetic dynamometer. Materials and Methods: This study consisted of a systematic review and the search for the theoretical composition was performed in the PubMed database using as descriptors the words muscle fatigue, knee, and isokinetic, and as filters the words Abstract available, Humans, Randomized Controlled Trial, and English language. It was not set limits for year of publications. Results: twenty nine studies were found, from which, seventeen were excluded due to exclusion criteria. Conclusion: It became evident in the present review that the greatest reduction in the peak torque occurs in protocols that use series of trials without determining the number of repetitions, requiring that the movement be executed until attaining exhaustion. However, if there is a need to determine a number of repetitions to decrease the the knee joint torque to the levels close to the one attained in the exhaustion protocol, the protocol that most reduced the knee joint flexor and extensor torque was the one that used five series of 30 repetitions with interval of one minute between series, independent of the angular speed and the type of contraction, concentric or excentric.