Journal of Morphological Sciences
http://www.jms.periodikos.com.br/article/587cb4bc7f8c9d0d058b483a
Journal of Morphological Sciences
Original Article

Meta-analysis about Atrial Natriuretic Peptide (ANP)

Ferro, M.; Witter, C.; De Souza, RR; Buriti, M. A.

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Abstract

Among the topics studied in physiology and aging, a hormone has been drawing attention from the scientific community: the Atrial Natriuretic Peptide (ANP). The ANP, which is produced by the cardiac atria, has demonstrated decisive action in endocrine mechanisms of action inhibiting sodium reabsorption in nephrons, revealing a direct influence on physiological mechanisms linked to aging and chronic stress.The overall objective of this study was to assess and analyze scientific literature on the ANP in the Pubmed database from 2010 to 2012. 30 articles were collected, verifying authorship and gender division of species, instruments and types of research. The results showed that the research of multiple authorship appeared mostly with 99.1%, being 51.8% of male authorship, 17.9% of female authorship and 29.5% of publications not identified. Research with only one author appears with 0.8% in total. As the types of species used, it was observed 50.3% of the works with humans, 40% with animals and 6.7% mixed (animal / human). As to the instruments used, the biochemical markers were the ones that stood out, with 30%, followed by label arterial pressure with 12, 2%, drugs, with 11.1% and microscopic studies with 10%. In the typology of research, biochemical research appears first, with 33.3%, followed by research morphophysiological/biochemical research, with 30%, Physiological / biochemical, with 26.7%, Physiological with 6.7% and Morphophysiological with 3.3%. We can conclude that the publications about the hormone ANP are still little explored when the focus is aging. In the analyzed publications, there is important information about the physiological and biochemical role of ANP as well as on their molecular composition.

Keywords

Atrial Natriuretic Peptide (ANP), heart disease, nephropathy and aging
587cb4bc7f8c9d0d058b483a jms Articles
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J. Morphol. Sci.

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