Introduction: The micro pathological changes in epidermis, nerves and skin appendages from skin lesion in leprosy are common but reports of involvement of apparently normal sites are few. During the latent period the apparently normal skin might also be undergoing some pathological changes. The objective of this study is to observe micro pathological changes in epidermis of apparently normal skin. Material and methods: We investigated skin biopsy material taken from 250 patients with clinically diagnosed leprosy. Biopsies were taken at least 10 cm away from site of lesion. Hematoxylin and eosin staining used to see histological changes in epidermis and Harada’s modified allochrome method used to demonstrate acid-fast bacillus. Z test of proportion was used to evaluate significant difference between different histological features. Results: The pattern of leprosy among the patients were indeterminate in 65 cases (26.0%), tuberculoid in 45 cases (18.0%), borderline tuberculoid in 38 cases (15.2%), borderline leprosy in 36 cases (14.4%), borderline lepromatous in 34 cases (13.6%) and leopromatous leprosy in 32 cases (12.8%). The epidermis of normal appearing skin showed flattening and thinning, erosion and presence of AFB. Conclusion: Micropathological changes were seen in epidermis of normal appearing skin in all forms of leprosy but involvement was greater at the lepromatous end of the spectrum compared to tuberculoid end. Significant difference observed between two variables and presence of AFB is also significant as far as dissemination and transmission of disease is concerned.