The luminal diameter, largest lymphoid follicular diameter, and serosal – mucosal circumference (wall thickness) of the vermiform appendix were measured in micrometers from the base, middle of appendix and near to tip and their relationship analysed and plotted. There is a strong relationship between the diameters, especially between lymphoid follicle diameter and mucosal serosal circumference (wall thickness) on the one hand and that between luminal diameter and largest lymphoid follicle diameter on the other. There is decrease in the luminal diameter, when either walls thickness, or the largest lymphoid follicle with the resulting histological and histomorphometric changes that can occur to bear in normal subjects. These profiles also explain the basis and common diameter increase in size, suggesting that obstruction can occur at these sites sites of obstruction in appendicitis.