Despite the advances in the treatment and prevention, myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide. Different degrees of ventricular dysfunction, changes in hemodynamic and molecular mechanisms, as well as neurohumoral derangements, are substantially associated with increased mortality rate in MI patients. Cardiovascular, metabolic and autonomic benefits of acute and chronic exercise training (ET) have led many researchers to suggest ET as an important tool in the management of coronary artery disease and after MI. Regarding cardiovascular rehabilitation, several factors, such as illness, injury, travel, vacation or even rehabilitation program discharge may often interfere with the ET process, leading to a disruption in physical activity patterns by either decreasing training level or frequency or interrupting the training program altogether. Thus, it is necessary to identify the impact of ET after MI, as well as the possible consequences of such disruption in infarcted individuals.