Macrodontia is a rare dental anomaly characterized by an excessive enlargement of all tooth structures that generally could be related with some syndromes. Until today, there is a low prevalence of bilateral macrodontia. The present report shows a patient with bilateral macrodontia in mandibular second premolars and with a clear medical history of him and his parents without any syndromes or other dental anomalies. It is important to know macrodontia because the crown shape of teeth is more predisposed to caries and may cause some problems in the occlusion of the patient. By the above, is important to acquire a deeper knowledge about this anatomical variation, as well as must be prepared to perform a carefully treatment of the compromised teeth. The aim of this study was to describe this case with a bilateral rare condition of interest to dentists.