The splenic artery has been reported to be tortuous in adults and remains the most vulnerable to atherosclerosis among the visceral branches of the abdominal aorta. The hepatic artery on the other hand is the least affected by atherosclerosis. Studies have shown that among other factors, flow patterns, which are dependent on the vessel geometry, may influence its micro architecture and consequently susceptibility to pathology. We sought to compare the histological organization of the human common hepatic and splenic arteries. Material and methods: Following approval from KNH – Ethics and Review committee and written consent obtained from deceased’s’ relatives fifteen specimens were obtained during autopsies conducted at the City and Chiromo. Subjects were aged between 21 and 44 years. Sections taken within 5 mm from origin were prepared for paraffin embedding and sectioning and stained using Masson’s trichrome and Weigert’s elastic stains. Results and conclusion: The splenic artery had prominent intimal thickenings, multiplication and fragmentation of the internal elastic lamina in the tunica intima and lacked external elastic lamina in the tunica media. The common hepatic artery was noted to have minimal intimal thickening, single continuous internal elastic lamina and prominent external elastic lamina. The features of the splenic artery suggests an adaptive role to increased blood flow and wall tension stress attributable to its tortuosity and may be part of the explanation for the higher incidence of atherosclerosis previously reported.