The larger palatine foramen (FPM), for being the emerging point of the vasculo neural bundle that it is distributed to the hard palate, for being close the area that donates gingival grafts, for being area for performing anesthetic techniques for desensitization of the hard palate, and still, for being the point of entrance of the palatine channel for reaching the pterigopalatine ganglion, becomes fundamental in oral surgery interventions. 141 softened human craniums were studied, from which 82 were masculine craniums and 59 were feminine craniums. The measures were collected with a “Mitutoyo” precision pachymetry, and a compass, among the reference points previously standardized. The collected data were submitted to the statistical analysis. The results of this research demonstrated that there was a significant difference between the measures of right and left FPMs in relation to the interpalatine suture. In most of the craniums, the FPM was located closer to the third molar. The masculine craniums presented dimensions significantly larger than the feminine craniums and, except for the distance between left FPM and the incisive foramen, all the other distances from the FPM to the points taken as reference can be considered to be considered in order to estimate the sex. It can be concluded that the results found diverged in relation to some of the literature reviewed. Some new studied are suggested, mainly studies that consider the incisive foramen and the maxillary tuber as reference points to define the topography of the larger palatine foramen.