Journal of Morphological Sciences
http://www.jms.periodikos.com.br/article/587cb4927f8c9d0d058b4754
Journal of Morphological Sciences
Original Article

Evaluation of the teratogenic potentials of ciprofloxacin in albino rat

M.A. Siddiqui; S.N.H. Naqvi

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Abstract

The safe use of medicines, both modern as well as traditional, during gestation is becoming an increasingly contentious issue because many therapeutic agents have proved to be menace as they produce congenital malformations in offspring when used during pregnancy. Objective: The present study was undertaken to investigate the effects of ciprofloxacin administration during gestation on young ones of albino rat. Material and Methods: Three hundred off springs of albino rat were used in this study. They were obtained from 60 pregnant rats at term or at 20th day of gestation. The pregnant rats were divided in four groups. Group A received ciprofloxacin in a dose of 15 mg.kg–1/day orally from 6th to 12th days of gestation. Groups B and C received 30 and 60 mg.kg–1/day orally for same period. Group D behaved as control and received 0.5 ml of distilled water orally for same period. The pregnant rats were observed for duration of pregnancy, weight gain, abortions and number of pups given birth. The obtained pups were examined for any structural malformations. Results: The weight gain of ciprofloxacin treated pregnant rats showed a significant decrease of 12.10, 17.91 and 24.87% as compared to control group animals. The incidence of abortion in treated animals was 7.1 and 9.1% as compared to none in controls. Mean number of pups delivered by treated animals (showed a highly significant decrease of 14.4, 21.6 and 27.7% as compared to controls. Mean weight of pups from treated animals showed a highly significant decrease of 16.12, 24.75 and 35.68% as compared to controls. Mean CRL of pups from treated animals showed a highly significant decrease of 17.42, 24.63 and 28.5% as compared to controls There were no resorptions in control group. Treated group A, B and C had incidences of 8.7, 30.6 and 36.4% resorptions respectively. No gross structural malformation was found in control or any of the treated groups. Conclusion: Ciprofloxacin was found to be embryo/feto toxic in terms of causing abortions, reduced no: of litter, retarded growth of young ones, fetal death and fetal resorptions in all doses tested.

Keywords

ciprofloxacin, pregnancy, congenital malformation
587cb4927f8c9d0d058b4754 jms Articles
Links & Downloads

J. Morphol. Sci.

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