Journal of Morphological Sciences
http://www.jms.periodikos.com.br/article/587cb48c7f8c9d0d058b4735
Journal of Morphological Sciences
Original Article

Immunohistochemical localization of tumor necrosis factor-alpha and interleukin-6-during orthodontic movement in rats

D. Milagres; C.R. Rueff-Barroso; A.M. Bolognese; A.M.A. Costa; L.C. Porto

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Abstract

The tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) are proinflammatory cytokines that have been associated to bone remodeling and bone deposition. However, their localization in the periodontal ligament (PDL) in vivo during the orthodontic movement is not well determined. TNF-α and IL-6 expression in PDL of maxillary rat incisors submitted to orthodontic movement was detected by immunohistochemistry at 6 and 12 hours and 4, 7, 21 and 28 days of force application. Alveolar bone lining cells expressed IL-6 in traction areas. In compression areas, some osteoblasts near osteoclasts expressed IL-6. TNF-α was essentially detected in osteoclasts, in compression areas, with 12 hours of force application. These cells expressed TNF-α and IL-6 in all time points studied. This study confirms that orthodontic force application induces TNF-α and IL-6 expression by PDL cells suggesting an essential role in bone–PDL remodeling.

Keywords

periodontal ligament, orthodontic, immunohistochemistry, TNF-α, IL-6
587cb48c7f8c9d0d058b4735 jms Articles
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J. Morphol. Sci.

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