The objective of this investigation was to carry out a literature review on the structural adaptations of the heart to physical exercises in the Chagas’ disease with search on PubMed, Web of Science, LILACS and MEDLINE databases using keywords in English without time restrictions. The Chagas’ disease, caused by a protozoan Trypanosoma cruzi, is one of the most important endemics that involve the inhabitants of Latin America. Its prevalence is estimated in approximately 10 to 12 million contaminated individuals, of which close to 3 million in Brazil, causing cardiopathies in 25% to 30% of those affected. Alterations in the structure and physiology of the cardiomyocytes became evident during the intracellular development of the T. cruzi. This infection promoves changes in the manifestation of the surface carbohydrates and modulates the intracellular traffic in cardiomyocytes. Individuals with the Chagas’ disease have myocardiac lesions with myocyte hypertrophy, chronic and fibrous myocarditis, influencing the appearance of arrythmias and the development of congestive cardiac insufficiency. There is a great accumulation of collagen in the interstice and perivascular space of the myocardium, promoving morphological, geometrical and functional alterations to the heart. During physical exercise the heart adjusts to the increases in the metabolic and mechanic physical activity, promoving biochemical, electrical, morphological and mechanical adaptations in the cardiac muscle that, altogether, provide improvement in the cardiac function.