The knowledge of the anatomical variations undergone by the infraorbital foramen (IOF) is important for the blockage of the infraorbital nerve and surgical maxillofacial procedures, as well. This study aims to analyze the morphometric variations of IOF in relation to gender and laterality in dry skulls of adult individuals in the south of Brazil, and the presence of the accessory infraorbital foramen (IOF). Seventy-two (72) male skulls and twenty-seven (27) female skulls were analyzed and used as parameters for the distance from the anterior nasal spine (ANS) to the IOF center; the distance from the lower rim of the orbital cavity to the center of the IOF; the angle from the ANS to the IOF, and the line from the ANS to the IOF. Comparisons were made between genders and sides of the skull, and the statistical analysis was carried out through the Student t-test. These results are essential to perform the nervous blockage and the surgical procedures in the periorbital section in order to avoid some damage to the neurovascular structures which cross this foramen.