Journal of Morphological Sciences
http://www.jms.periodikos.com.br/article/587cb4547f8c9d0d058b45f0
Journal of Morphological Sciences
Original Article

EFFECTS OF AGGRECAN ON SCHWANN CELL MIGRATION in vitro AND NERVE REGENERATION in vivo

Amauri Pierucci; Aline Macedo Faria; Edson Rosa Pimentel; Arnaldo Rodrigues Santos Júnior; Alexandre Leite Rodrigues de Oliveira

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Abstract

Although the role of many small proteoglycans in regeneration of the nervous system has been established, little is known about the involvement of large proteoglycans. In this study, we evaluated the effects of aggrecan, a high molecular mass proteoglycan, on Schwann cells in vitro and investigated its effects on axonal regeneration after sciatic nerve tubulization. The number of regenerated axons and their morphometrical parameters were determined in vivo. Aggrecan increased the number and viability of Schwann cells in vitro. Similarly, the number of regenerated fibers increased significantly when aggrecan was applied in vivo, but there were no alterations in the morphometrical parameters. These results indicate that aggrecan contributes to the regeneration of peripheral axons and has a positive effect on the Schwann cells.

Keywords

Cell culture, extracellular matrix, glycosaminoglycans, proteoglycans, tubulization
587cb4547f8c9d0d058b45f0 jms Articles
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J. Morphol. Sci.

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