Journal of Morphological Sciences
http://www.jms.periodikos.com.br/article/587cb44d7f8c9d0d058b45c8
Journal of Morphological Sciences
Original Article

THE INFLUENCE OF HYDROXYAPATITE ON BONE HEALING IN TITANIUM IMPLANTS AS SHOWN BY SCANNING ELECTRON MICROSCOPY

Liliane Elze Falcão Lins; Edmar José Borges de Santana; Antonio Fernando Pereira Falcão; Pedro Paulo Monteiro Martins; Tereza Raquel Vianna Calmon; Viviane Almeida Sarmento

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Abstract

Hydroxyapatite is a biomaterial with osteoconductive properties and its use in implants may accelerate bone healing. In this work, scanning electron microscopy (SEM) was used to examine the influence of hydroxyapatite on bone healing in titanium implants in a rabbit tibial model. Two titanium implants 6 mm long and 3.17 mm in diameter were inserted into the right tibial metaphysis of each of five rabbits. The proximal implant served as the control and the distal one (experimental group) was filled with hydroxyapatite. Forty-two days after implantation, the rabbits were sacrificed and the implants analyzed. Tissue fragments with the implants were examined by SEM. Compact and trabecular bone were observed along the entire internal surface of implants filled with hydroxyapatite, but not in all of the control cases. In contrast, marrow bone retraction occurred on the internal surface of the implants in the control group but not in the experimental group (p<0.05). These results show that hydroxyapatite was well accepted by bone tissue in this experimental model and that there was no inflammatory reaction between the fibroblast processes and hydroxyapatite granules. In addition, hydroxyapatite accelerated the bone healing in osseointegrated implants.

Keywords

Dental implantation, hydroxyapatite, rabbits, scanning electron microscopy, titanium
587cb44d7f8c9d0d058b45c8 jms Articles
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J. Morphol. Sci.

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