Journal of Morphological Sciences
http://www.jms.periodikos.com.br/article/587cb4477f8c9d0d058b45a6
Journal of Morphological Sciences
Original Article

THE EFFECT OF TRIETHYLCITRATE ON THE POROSITY AND BIOCOMPATIBILITY OF POLY(LACTIC ACID) MEMBRANES

Rubens Monteiro Luciano; Eliana Aparecida Rezende Duek; Maria do Carmo Alberto-Rincon

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Abstract

The aim of this study was to investigate stability and tissue response to poly (L-lactic acid) (PLLA) membranes implanted in sub-dermal tissue of rats. Membranes with and without plasticizer (triethylcitrate) were compared. Membranes without plasticizer were denser and more compact than those with triethylcitrate. Fifteen days and 30 days after implantation, the membranes with tissue adhered were removed and processed for light microscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). By 15 days post-implantation, membranes lacking plasticizer showed invasion of the pores by connective tissue. Thirty days after implantation, the pores of membranes with plasticizer were invaded by blood vessels, and multi-nucleated giant cells surrounded by globular units of the membranes. Membrane debris was also detected in the cytoplasm of multi-nucleated giant cells. These data show that the addition of plasticizer to PLLA results in a more porous membrane, therefore enabling them more suitable in tissue repair (than membranes without plasticizer).

Keywords

Biocompatibility, connective tissue, implants, poly (lactic acid), porosity, triethylcitrate
587cb4477f8c9d0d058b45a6 jms Articles
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J. Morphol. Sci.

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